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Definition: Newid mawr a sydyn mewn feirws, sy'n arwain at broteinau newydd ar arwyneb y feirws eu hun. Gall hyn olygu bod is-fath newydd o feirws yn dod i fodolaeth, sy'n fwy tebygol o heintio pobl.
Notes: Cymharer ag antigenic drift / drifft antigenig.